abstract：:Intrinsic exercise capacity is predictive of both lifespan and healthspan but whether adaptive exercise capacity influences the benefits achieved from aerobic training implemented later in life is not known. AIM:To determine if exercise late in life provides any functional improvements or underlying beneficial bioche...

journal_title：Experimental gerontology

authors： Brown LA,Macpherson PC,Koch LG,Qi NR,Britton SL,Brooks SV

更新日期：2019-10-01 00:00:00

abstract：:The age-related decrease in neuromuscular performance is usually accentuated in very old age (>80 yr) as evidenced by a marked reduction in maximal force production. However, little is known about the ability to rapidly produce force, which limits daily activities and increase the risk of falling. We aimed to assess r...

journal_title：Experimental gerontology

authors： Varesco G,Espeit L,Feasson L,Lapole T,Rozand V

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:1) To determine if there was a practice effect associated with walk tests performed by frail older adults with and without dementia, 2) to examine the role of systematic cueing in the walk tests for those with dementia, and 3) to make recommendations to testing protocols of the walk tests for frail older adu...

journal_title：Experimental gerontology

authors： Chan WLS,Pin TW

更新日期：2019-09-01 00:00:00

abstract：:Permethrin is a synthetic pyrethroid extensively used as anti-woodworm agent and for indoor and outdoor pest control. The main route of human exposure is through fruit, vegetable and milk intake. Low dosage exposure to permethrin during neonatal brain development (from postnatal day 6 to postnatal day 21) leads to dop...

journal_title：Experimental gerontology

authors： Bordoni L,Nasuti C,Fedeli D,Galeazzi R,Laudadio E,Massaccesi L,López-Rodas G,Gabbianelli R

更新日期：2019-09-01 00:00:00

abstract：:Acute illness requiring hospitalization is a sentinel event leading to functional decline and frequently, long-term disability in older adults. Although functional decline has become a key outcome during and after hospitalization, there is currently no gold standard for measuring functional impairment. The purpose of ...

journal_title：Experimental gerontology

authors： Sáez de Asteasu ML,Martínez-Velilla N,Zambom-Ferraresi F,Casas-Herrero Á,Ramirez-Vélez R,Izquierdo M

更新日期：2019-09-01 00:00:00

abstract：:Threat-related changes in postural control and their associations with changes in emotional and cognitive states are influenced by postural threat experience, however, limited work has explored individuals' capacity to adapt threat-related responses over longer periods of threat exposure. This study examined the effec...

journal_title：Experimental gerontology

authors： Johnson KJ,Zaback M,Tokuno CD,Carpenter MG,Adkin AL

更新日期：2019-07-15 00:00:00

abstract：:Aging is a physiological process characterized by an age-progressive decline in intrinsic physiological functions, with an increased risk of developing chronic metabolic conditions, such as insulin resistance and diabetes. Furthermore, from a physiopathological point of view, several authors describe an association be...

journal_title：Experimental gerontology

authors： Zoico E,Rizzatti V,Policastro G,Tebon M,Darra E,Rossi AP,Mazzali G,Fantin F,Zamboni M

更新日期：2019-07-01 00:00:00

abstract：:Mouse models have been widely used in the research of human diseases. Aging, just as cancer, is influenced by the interaction of various genetic and environmental factors. Currently, aging could be induced by many mechanism, including telomere dysfunction, oxidase stress, DNA damage and epigenetic changes. Many of the...

journal_title：Experimental gerontology

authors： Li H,Wei C,Zhou R,Wang B,Zhang Y,Shao C,Luo Y

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Physical activity and sedentary behavior are modifiable risk factors for non-communicable disease and healthy ageing, however the majority of older adults remain insufficiently active. Digital behavior change interventions (DBCI) have the potential to reach many older adults to promote physical activity and ...

journal_title：Experimental gerontology

authors： Stockwell S,Schofield P,Fisher A,Firth J,Jackson SE,Stubbs B,Smith L

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:The ageing process can be influenced by different dietary patterns and dietary factors. AIM:To analyse the association of dietary factors, which include the Mediterranean diet adherence, the compliance with the "Sociedad Española de Nutrición Comunitaria" food portion recommendations, and the intake of di...

journal_title：Experimental gerontology

authors： Jurado-Fasoli L,Amaro-Gahete FJ,De-la-O A,Martinez-Tellez B,Ruiz JR,Gutiérrez Á,Castillo MJ

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:To explore the impact of diabetic peripheral neuropathy (DPN) on the recovery of older persons with diabetes mellitus (DM) after hip-fracture surgery. DESIGN, SETTING, PARTICIPANTS:Secondary data for this study came from a clinical trial on the effectiveness of a DM-specific care model for 176 ol...

journal_title：Experimental gerontology

authors： Tseng MY,Huang YF,Liang J,Wang JS,Yang CT,Wu CC,Cheng HS,Chen CY,Lin YE,Wang WS,Shyu YL

更新日期：2019-05-01 00:00:00

abstract：:This study examined the beneficial effects of black rice anthocyanin extract (BRAE), which provides as an excellent source of dietary antioxidants, on the lifespan of fruit flies and the underlying molecular mechanisms. Results showed that supplementation of BRAE extended the lifespan of fruit flies by 20% and retarde...

journal_title：Experimental gerontology

authors： Li X,Zhang Z,Zhang X,Cheng J,Liu D,Yan Y,Wang H

更新日期：2019-05-01 00:00:00

abstract：:Neural correlates of placebo analgesia (PA) in patients with neurocognitive disorders have not yet been elucidated. The present study aimed to evaluate how and to what extent executive (dys)functions of the medial prefrontal cortex (MPFC) may be related to PA. To this end, twenty-three subjects complaining of differen...

journal_title：Experimental gerontology

authors： Palermo S,Rainero I,Stanziano M,Vase L,D'Agata F,Rubino E,Fonio P,Sardanelli F,Amanzio M

更新日期：2019-04-01 00:00:00

abstract：:Gene expression is much altered in aging. We observed age-dependent decline of core clock genes' expression in the whole body of the fruit fly. We hypothesized that inducible overexpression of clock genes (cry, per, tim, cyc and Clk) in the nervous system can improve healthspan of D. melanogaster. We studied the lifes...

journal_title：Experimental gerontology

authors： Solovev I,Dobrovolskaya E,Shaposhnikov M,Sheptyakov M,Moskalev A

更新日期：2019-03-01 00:00:00

abstract：:Mistiming of circadian rhythms impairs quality of life. The sleep fragmentation that results can lead to fatigue, mood alteration, and short-term memory problems. Unfortunately, this suite occurs in humans as we age. In the current study, we used high-resolution monitors to track how circadian patterns of locomotor ac...

journal_title：Experimental gerontology

authors： Kaladchibachi S,Secor MA,Negelspach DC,Fernandez F

更新日期：2019-02-01 00:00:00

abstract：:Every organism must adapt and respond appropriately to the source of nutrients available in its environment. Different mechanisms and pathways are involved in detecting the intracellular and extracellular levels of macronutrients including amino acids. Detection of amino acids in food sources is provided by taste cell...

journal_title：Experimental gerontology

authors： Lushchak O,Strilbytska OM,Yurkevych I,Vaiserman AM,Storey KB

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Geriatric depression is common due to the high rate of chronic diseases suffered by the older population. There is a well-established effect of exercise on one's wellbeing, however, for the elderly females there is dearth in research addressing exercise and its effect on their neurotransmitters and depressio...

journal_title：Experimental gerontology

authors： Kim YS,O'Sullivan DM,Shin SK

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Awareness of physical ability may impact fall risk during everyday tasks. Therefore, we investigated perceived reach (PR; estimation of furthest reach distance), maximal reach (MR) and reach judgement error (RJE), and their relationships with neuropsychological and physical performance, and falls in older pe...

journal_title：Experimental gerontology

authors： Taylor ME,Butler AA,Lord SR,Delbaere K,Kurrle SE,Mikolaizak AS,Close JCT

更新日期：2018-12-01 00:00:00

abstract：:There is currently no test to directly and easily measure dynamic balance during walking in old adults. We examined the idea that distance of beam walking with and without cognitive dual-tasking could detect age differences in dynamic balance. Healthy old (n = 16, 71.2 y) and young (n = 20, 22.0 y) volunteers walked 3...

journal_title：Experimental gerontology

authors： Uematsu A,Tsuchiya K,Suzuki S,Hortobágyi T

更新日期：2018-12-01 00:00:00

abstract：:Recently, it has been suggested that oxytocin (OT) might play a role in the control of bone remodeling and in bone health of young and adult females. The purpose of this study was to evaluate the effect of osteogenic medium (OM) plus OT (OM + OT; 100 nmol/L) on osteoblastic differentiation of bone marrow mesenchymal s...

journal_title：Experimental gerontology

authors： Santos LF,Singulani MP,Stringhetta-Garcia CT,Oliveira SHP,Chaves-Neto AH,Dornelles RCM

更新日期：2018-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by amyloid-β plaques, tau pathology and vascular impairment including pericyte damage. Pericytes are perivascular cells of the blood-brain barrier and can differentiate into different cell types in vitro including microglia. The aim of the present study is to explore if primar...

journal_title：Experimental gerontology

authors： Hutter-Schmid B,Humpel C

更新日期：2018-10-02 00:00:00

abstract：:Plantar-flexor muscles are key muscles in the control of postural sway. Older fallers present lower maximal plantar-flexor performance than older non-fallers; however, the mechanisms underlying this motor impairment remain to be elucidated. This study aimed to determine whether muscular and neural factors are both inv...

journal_title：Experimental gerontology

authors： Cattagni T,Harnie J,Jubeau M,Hucteau E,Couturier C,Mignardot JB,Deschamps T,Berrut G,Cornu C

更新日期：2018-10-02 00:00:00

abstract：BACKGROUND:Oxidative stress and inflammation may contribute to anabolic resistance in response to protein and exercise in older adults. We investigated whether consumption of montmorency cherry concentrate (MCC) increased anabolic sensitivity to protein ingestion and resistance exercise in healthy older men. METHODS:S...

journal_title：Experimental gerontology

authors： Jackman SR,Brook MS,Pulsford RM,Cockcroft EJ,Campbell MI,Rankin D,Atherton P,Smith K,Bowtell JL

更新日期：2018-09-01 00:00:00

abstract：:A growing body of research in elderly populations suggests that the early phase of an explosive muscle contraction (i.e., ≤200 ms) may be more functionally relevant than peak values. However, age-related variation in early phase explosive strength has never been investigated across the full-adult life span. This cross...

journal_title：Experimental gerontology

authors： Van Roie E,Van Driessche S,Inglis AJ,Thomis M,Delecluse C

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Aging leads to poorer neuromuscular control that may impact mobility. However, the specific decades when these changes occur, and whether these time-based changes are sex-specific, are unclear. METHODS:Adults aged 20-82 years (N = 93, 51 females) walked six gait trials at their preferred speed over a 10-m...

journal_title：Experimental gerontology

authors： Bailey CA,Corona F,Pilloni G,Porta M,Fastame MC,Hitchcott PK,Penna MP,Pau M,Côté JN

更新日期：2018-09-01 00:00:00

abstract：:We investigated the effects of angiotensin-converting enzyme (ACE) inhibition and aerobic physical training on the heart of old female rats (82-wk-old) submitted to premature ovarian failure (10-wk.-old). We used different approaches: morphology and function by echocardiography, reactivity of the coronary bed and left...

journal_title：Experimental gerontology

authors： Felix ACS,Dutra SGV,Gastaldi AC,Bonfim PC,Vieira S,de Souza HCD

更新日期：2018-08-01 00:00:00

abstract：:The purpose of this study was to examine the relative contributions of changes in muscle quality and body composition to changes in lower-extremity physical function (LEPF) following a 6-month exercise and weight loss intervention in overweight and obese older women. Thirty-eight overweight and obese (BMI = 30.0 ± 4.4...

journal_title：Experimental gerontology

authors： Straight CR,Berg AC,Reed RA,Johnson MA,Evans EM

更新日期：2018-07-15 00:00:00

abstract：PURPOSE:Aging changes the balance of sex hormones and causes endothelial dysfunction in the penis, both of which are important determinants of erectile dysfunction (ED). The purpose of this study was to evaluate whether exercise training could protect against erectile dysfunction by increasing serum testosterone and pe...

journal_title：Experimental gerontology

authors： Seo DY,Lee SR,Kwak HB,Park H,Seo KW,Noh YH,Song KM,Ryu JK,Ko KS,Rhee BD,Han J

更新日期：2018-07-15 00:00:00

abstract：:The aim of the present study was to compare the effects of water-based aerobic training and water-based resistance training on muscular strength and cardiorespiratory fitness in older women. Sixty-nine individuals were randomized into the following three groups: the water-based aerobic training (WA, n = 23) group, the...

journal_title：Experimental gerontology

authors： Costa RR,Kanitz AC,Reichert T,Prado AKG,Coconcelli L,Buttelli ACK,Pereira LF,Masiero MPB,Meinerz AP,Conceição MO,Sbeghen IL,Kruel LFM

更新日期：2018-07-15 00:00:00

abstract：BACKGROUND:Homocysteine (Hcy) high levels are associated with fractures, bone resorption and an early onset of osteoporosis in elderly persons; a relationship between Hcy and bone formation has also been suggested but is still controversial. Frailty, an independent predictor of fractures and decreased bone mineral dens...

journal_title：Experimental gerontology

authors： Álvarez-Sánchez N,Álvarez-Ríos AI,Guerrero JM,García-García FJ,Rodríguez-Mañas L,Cruz-Chamorro I,Lardone PJ,Carrillo-Vico A

更新日期：2018-07-15 00:00:00

abstract：:Declines in mobility with advancing age are often associated with a reduction in the use of lower leg muscles. We examined the influence of two interventions that involved neuromuscular electrical stimulation (NMES) applied to the triceps surae muscles on the mobility and muscle function of older adults. Thirty health...

journal_title：Experimental gerontology

authors： Mani D,Almuklass AM,Amiridis IG,Enoka RM

更新日期：2018-07-15 00:00:00

abstract：INTRODUCTION:The actual mechanisms leading to a reduced muscle power and functional ability in older adults are poorly understood. We investigated the association between different force-velocity (F-V) profiles and impaired muscle power, physical and cognitive function, frailty, and health-related quality of life (HRQo...

journal_title：Experimental gerontology

authors： Alcazar J,Rodriguez-Lopez C,Ara I,Alfaro-Acha A,Rodríguez-Gómez I,Navarro-Cruz R,Losa-Reyna J,García-García FJ,Alegre LM

更新日期：2018-07-15 00:00:00

abstract：BACKGROUNDS:Elucidating the causal effects of common intermediate risk factors on the onset of age-related diseases is indispensable for developing prevention and intervention procedures. METHODS:We conducted two-stage time-to-event Mendelian randomization meta-analyses combining five large-scale longitudinal cohorts ...

journal_title：Experimental gerontology

authors： He L,Culminskaya I,Loika Y,Arbeev KG,Bagley O,Duan M,Yashin AI,Kulminski AM

更新日期：2018-07-01 00:00:00

abstract：:Dietary restriction (DR) has multiple and essential effects in protecting against DNA damage in model organisms. Persistent DNA damage plays a central role in the process of aging. Senescence-associated secretory phenotype (SASP), as a product of cellular aging, can accelerate the process of cellular senescence as a f...

journal_title：Experimental gerontology

authors： Wang W,Cai G,Chen X

更新日期：2018-07-01 00:00:00

abstract：:Senescent cells accumulate with age and contribute to pathologies associated to old age. The senescent program can be induced by pro-cancer stimuli or is developmentally controlled. In cells forced to senesce by expression of oncogenes or short telomeres, aberrant activation of the ERK/MAP kinase signaling pathway lea...

journal_title：Experimental gerontology

authors： Ferbeyre G

更新日期：2018-07-01 00:00:00

abstract：:Alzheimer's disease is one of the most devastating neurodegenerative diseases. The exact cause of the disease is still not known although many scientists believe in the beta amyloid hypothesis which states that the accumulation of the amyloid peptide beta (Aβ) in brain is the initial cause which consequently leads to ...

journal_title：Experimental gerontology

authors： Le Page A,Dupuis G,Frost EH,Larbi A,Pawelec G,Witkowski JM,Fulop T

更新日期：2018-07-01 00:00:00

abstract：:Fatigue is a common complaint in older people. Laboratory-induced muscle fatigue has been found to affect physical functions in older populations but these protocols are rigorous and are unlikely to accurately reflect daily activities. This study used an ecological approach to determine the effects of a busy day on se...

journal_title：Experimental gerontology

authors： Sturnieks DL,Yak SL,Ratanapongleka M,Lord SR,Menant JC

更新日期：2018-06-01 00:00:00

abstract：:Atrophy of the thymus, the primary site of T lymphocyte generation, is a hallmark of the aging immune system. Age-associated thymic atrophy results in diminished output of new, naïve T cells, with immune sequelae that include diminished responses to novel pathogenic challenge and vaccines, as well as diminished tumor ...

journal_title：Experimental gerontology

authors： Cepeda S,Griffith AV

更新日期：2018-05-01 00:00:00

abstract：:Post-viral pneumococcal pneumonia is a leading morbidity and mortality in older patients (≥65years of age). The goal of our current study is to understand the impact of chronological aging on innate immune responses to a secondary, post viral infection with Streptococcus pneumoniae, a causative agent of bacterial pneu...

journal_title：Experimental gerontology

authors： Cho SJ,Plataki M,Mitzel D,Lowry G,Rooney K,Stout-Delgado H

更新日期：2018-05-01 00:00:00

abstract：:Aging has a profound effect on the immune system, and both innate and adaptive arms of the immune system show functional decline with age. In response to infection with intracellular microorganisms, old animals mobilize decreased numbers of antigen-specific CD8+ T cells with reduced production of effector molecules an...

journal_title：Experimental gerontology

authors： Jergović M,Smithey MJ,Nikolich-Žugich J

更新日期：2018-05-01 00:00:00